N-Ethyltetrahydrofurfurylamine → tert-Butyl 4-(ethyl((tetrahydrofuran-2-yl)methyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

HRID 1930667Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1930667
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13]3[N:14]=[C:15](OS(C(F)(F)F)(=O)=O)[C:16]4[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.[O:38]1[CH2:42][CH2:41][CH2:40][CH:39]1[CH2:43][NH:44][CH2:45][CH3:46]>CN(C=O)C>[CH2:45]([N:44]([CH2:43][CH:39]1[CH2:40][CH2:41][CH2:42][O:38]1)[C:15]1[C:16]2[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:27])[CH3:28])=[O:24])[CH2:20][CH2:19][C:17]=2[N:18]=[C:13]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([C:5]3[O:1][CH:2]=[N:3][CH:4]=3)=[CH:7][CH:8]=2)[N:14]=1)[CH3:46]

Komponenten

4

Edukt 2

HCID 98295N-EthyltetrahydrofurfurylamineHCID 59333731tert-butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Produkt 1

HCID 59333809tert-Butyl 4-(ethyl((tetrahydrofuran-2-yl)methyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

tert-Butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (350 mg, 0.65 mmol, example 1b) was dissolved in DMF (2 mL). N-((tetrahydrofuran-2-yl)methyl)ethanamine (84 mg, 0.65 mmol) was added and the reaction was stirred at 80° C. overnight. The solvent was evaporated under reduced pressure and the crude was used as such in the subsequent step.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-73a85df21b434ee7ba178983b2000d17
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188101B2

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