HRID1930667

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID98295

N-Ethyltetrahydro-2-furanmethanamine

C7H15NO

结构：CC(C)(C)OC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(OS(=O)(=O)C(F)(F)F)c2C1

HCID59333731

未命名化合物

PRODUCTS

生成物

结构：CCN(CC1CCCO1)c1nc(Nc2ccc(-c3cnco3)cc2)nc2c1CN(C(=O)OC(C)(C)C)CC2

HCID59333809

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

tert-Butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (350 mg, 0.65 mmol, example 1b) was dissolved in DMF (2 mL). N-((tetrahydrofuran-2-yl)methyl)ethanamine (84 mg, 0.65 mmol) was added and the reaction was stirred at 80° C. overnight. The solvent was evaporated under reduced pressure and the crude was used as such in the subsequent step.

WORKUP

后处理

customThe solvent was evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-73a85df21b434ee7ba178983b2000d17
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08188101B2
来源说明: uspto-grants-2012_05

反应 SMILES

[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13]3[N:14]=[C:15](OS(C(F)(F)F)(=O)=O)[C:16]4[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.[O:38]1[CH2:42][CH2:41][CH2:40][CH:39]1[CH2:43][NH:44][CH2:45][CH3:46]>CN(C=O)C>[CH2:45]([N:44]([CH2:43][CH:39]1[CH2:40][CH2:41][CH2:42][O:38]1)[C:15]1[C:16]2[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:27])[CH3:28])=[O:24])[CH2:20][CH2:19][C:17]=2[N:18]=[C:13]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([C:5]3[O:1][CH:2]=[N:3][CH:4]=3)=[CH:7][CH:8]=2)[N:14]=1)[CH3:46]