HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930671Generated: October 31, 2026
(S)-(+)-Tetrahydrofurfurylamine → HCID 59333740, compound
https://huagongshe.com/reaction/1930671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (S)-(+)-Tetrahydrofurfurylamine | HCID 641530 | — |
| Reactant | tert-butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate | HCID 59333731 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59333740 | HCID 59333740 | — |
Reaction Steps
tert-Butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (350 mg, 0.65 mmol, example 1b) was dissolved in DMF (2 mL). (S)-(tetrahydrofuran-2-yl)methanamine was added and the reaction mixture was stirred at 80° C. for 3 h. The solvent was evaporated under reduced pressure and the crude used in the subsequent step without purification. MS (ES+) m/z 493.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08188101B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-937503aa65d141b0921fee0895cc0e74 |
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| Source note | uspto-grants-2012_05 |
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