Sodium ethoxide → HCID 46199897, compound

Participants

Reaction Steps

1-(4-(2-Methyl-1H-imidazol-1-yl)phenyl)guanidine (953 mg, 4.43 mmol, example 9e), 5-phenylhexane-2,4-dione (842 mg, 4.43 mmol) and sodium ethoxide (301 mg, 4.43 mmol) in ethanol (5 mL) were heated in a microwave reactor at 100° C. for 15 minutes. The mixture was allowed to reach room temperature and the crude was purified by HPLC yielding 4-methyl-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-6-(1-phenylethyl)pyrimidin-2-amine (23.00 mg, 1.313%). MS (ES+) m/z 370.2 (M+H)+

Provenance & Evidence