Water → 6-acetyl-2-[4-(1,3-oxazol-5-yl)anilino]-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one

Participants

Reaction Conditions

Reaction Steps

1-(4-(Oxazol-5-yl)phenyl)guanidine (2 g, 9.89 mmol, example 1e), methyl 1-acetyl-4-oxopiperidine-3-carboxylate (1.970 g, 9.89 mmol) and sodium ethoxide (0.673 g, 9.89 mmol) in ethanol were charged in a thick wall glass which was sealed and heated at 100° C. under microwave irradiation. The reaction mixture was allowed to reach room temperature and water was added until a solid was obtained. The solid was filtered and dried in a vacuum oven at 40° C. overnight yielding 1-(4-hydroxy-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (1.400 g, 40.3%).

Provenance & Evidence