HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-N-methylaniline → HCID 46199899, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-N-methylaniline | HCID 68024 | — |
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | 6-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate | HCID 59333760 | — |
| Product | HCID 46199899 | HCID 46199899 | 18% |
Reaction Steps
1-(4-((4-fluorophenyl)(methyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (15 mg, 18%) was prepared from 4-fluoro-N-methylaniline and 6-acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate (example 88a) according to the general procedure for amine substitution of tosylate on pyrimidines.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188101B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-36061ae5afd946038062c6c9e458be44 |
| Source note | uspto-grants-2012_05 |