HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonate → HCID 46200057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | Piperidin-2-ylmethanol | HCID 94263 | — |
| Reactant | 6-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate | HCID 59333760 | — |
| Product | HCID 46200057 | HCID 46200057 | 56.4% |
Reaction Steps
1-(4-(2-(Hydroxymethyl)piperidin-1-yl)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (18.3 mg, 56.4%) was prepared from piperidin-2-ylmethanol and 6-acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate (example 88a) according to the general procedure for amine substitution of tosylate on pyrimidines.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188101B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-733bfea08c3e4099ba56cf66f6e903c9 |
| Source note | uspto-grants-2012_05 |