Acetic Acid → HCID 46200058, compound

Participants

Reaction Steps

Formaldehyde (3.15 μL, 0.04 mmol) was added to a solution of N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-(3-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (13.70 mg, 0.03 mmol) in methanol (1.5 mL). Sodium cyanoborohydride (0.943 mg, 0.02 mmol) and acetic acid (1.030 μL, 0.02 mmol) was added and the reaction mixture stirred for 2 h at rt and purified by preparative HPLC to afford the titled compound.

Provenance & Evidence