Dichloromethane → HCID 67423402, compound

Participants

Reaction Steps

tert-Butyl 3-(2-(3-methoxyphenyl)acetyl)-4-oxopiperidine-1-carboxylate (320 mg, 0.92 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine dinitrate (342 mg, 0.92 mmol, example 43a) and potassium carbonate (382 mg, 2.76 mmol) in ethanol (4 mL) was heated in a microwave reactor to 130° C. for 3 hours. DCM and water was added and the organic phases were separated, dried with MgSO4, concentrated and purified by preparative HPLC to afford tert-butyl 2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-4-(3-methoxybenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (15.00 mg, 3%).

Provenance & Evidence