Acetic Anhydride → HCID 46200203, compound

Participants

Reaction Steps

N-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-(3-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (137 mg, 0.3 mmol, example 95a) was dissolved in DCM (3 mL) and acetic anhydride (0.028 mL, 0.30 mmol) was added. The crude product was purified by preparative HPLC yielding 1-(2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-4-(3-methoxybenzyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (25.00 mg, 16.7%).

Provenance & Evidence