Ethanol → HCID 46200206, compound

Participants

Reaction Conditions

Reaction Steps

2-(2-(4-Fluorophenyl)acetyl)-4-(trifluoromethyl)cyclohexanone (75 mg, 0.25 mmol), 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (53.4 mg, 0.25 mmol) and potassium carbonate (68.6 mg, 0.50 mmol) were added to a microwave vial. EtOH (3 mL) was added and the reaction was heated to 130° C. for 2 h. DCM (3 mL) and water (3 mL) were added. The organic phase was separated and the solvent was evaporated. The product was purified by preparative HPLC yielding 4-(4-fluorobenzyl)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinazolin-2-amine (30.0 mg, 25.1%).

Provenance & Evidence