Bromoacetonitrile → 2-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)acetonitrile

Participants

Reaction Steps

Bromoacetonitrile (0.031 mL, 0.45 mmol) was added to a solution of 4-benzyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (175 mg, 0.41 mmol, Example 106) and TEA (0.063 mL, 0.45 mmol) in THF (3 mL). The solution was stirred at RT for 2 hours. Solvent was evaporated and the crude product was purified on a prepHPLC yielding 2-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)acetonitrile (72.0 mg, 37.7%). MS (ES+) m/z 466.3 (M+H)+

Provenance & Evidence