tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 59333803, compound

HRID 1930715Notes

Reaction equation

HRID 1930715 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH:8]([CH3:12])[C:9](Cl)=[O:10])[N:3]=1.[O:13]=[C:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1>>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH:8]([CH3:12])[C:9]([CH:19]2[C:14](=[O:13])[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18]2)=[O:10])[N:3]=1

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 59333819HCID 59333819, compound

Product 1

HCID 59333803HCID 59333803, compoundYield 23.9%

Procedure

tert-Butyl 3-(2-(3,5-dimethyl-1H-pyrazol-1-yl)propanoyl)-4-oxopiperidine-1-carboxylate (0.248 g, 23.87% yield) was synthesised from 2-(3,5-dimethyl-1H-pyrazol-1-yl)propanoyl chloride (0.5 g, 2.97 mmol, example 104b) and tert-butyl 4-oxopiperidine-1-carboxylate (1.185 g, 5.95 mmo) by the general procedure for the preparation of diketones.

Sources & evidence

ORD record
ord-687c4e7f980041f4bed5916abb0b58bb
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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