Acetic Anhydride → HCID 59333752, compound

Participants

Reaction Steps

To a solution of N -(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-(2-(tetrahydrofuran-2-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (0.114 g, 0.26 mmol) in dichloromethane (2 mL) was added acetic anhydride (0.027 mL, 0.29 mmol) at rt. The reaction mixture was stirred for 45 minutes. The solvent was concentrated; the residue was suspended with methanol and purified by prepHPLC. Fractions were pooled and the solvent was evaporated. The residue was dissolved in water/acetonitrile-mixture (50:50) and freezedried giving 1-(2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-4-(2-(tetrahydrofuran-2-yl)ethyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (0.062 g, 49.6%).

Provenance & Evidence