m-Chloroperbenzoic acid → HCID 59333794, compound

Participants

Reaction Steps

4-Benzyl-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (90 mg, 0.22 mmol) and mCPBA (56.3 mg, 0.33 mmol) was dissolved in DCM (4 mL). The reaction was completed after 2 h. The solvent was evaporated and the crude product was purified on preparative HPLC yielding 4-benzyl-N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine 6-oxide (13.0 mg, 13.0%). MS (ES+) m/z 430.0 (M+H)+

Provenance & Evidence