HCID 59333797, compound → HCID 59333701, compound

HRID 1930732Notes

Reaction equation

HRID 1930732 reaction equation
[C:1]1([CH2:7][C:8]([CH:10]2[C:15](=O)[CH2:14][CH2:13][S:12][CH2:11]2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1[N:19]([C:23]2[CH:28]=[CH:27][C:26]([NH:29][C:30]([NH2:32])=[NH:31])=[CH:25][CH:24]=2)[CH:20]=[CH:21][N:22]=1>>[CH2:7]([C:8]1[C:10]2[CH2:11][S:12][CH2:13][CH2:14][C:15]=2[N:32]=[C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([N:19]3[CH:20]=[CH:21][N:22]=[C:18]3[CH3:17])=[CH:24][CH:25]=2)[N:31]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 59333797HCID 59333797, compoundHCID 178432900HCID 178432900, compound

Product 1

HCID 59333701HCID 59333701, compoundYield 28%

Procedure

4-Benzyl-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (74 mg, 28%) was synthesised from 3-(2-phenylacetyl)dihydro-2H-thiopyran-4(3H)-one and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for the synthesis of pyrimidines. MS (ES+) m/z 414.2 (M+H)+

Sources & evidence

ORD record
ord-1e89de0caacd490a8686edb9a3089386
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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