Ethyl isothiocyanate → HCID 178465512、化合物

HRID 1930738ノート

反応式

HRID 1930738 の反応式
[F:1][C:2]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[N:17]=[C:18]([CH2:21][O:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[NH:19][CH:20]=3)=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:29]([N:31]=[C:32]=[S:33])[CH3:30]>C(O)C>[CH2:29]([NH:31][C:32]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([O:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[N:17]=[C:18]([CH2:21][O:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[NH:19][CH:20]=3)=[CH:14][CH:15]=2)=[CH:8][C:2]=1[F:1])=[S:33])[CH3:30]

参加物

4

反応物 2

HCID 10966Ethyl isothiocyanateHCID 178507749HCID 178507749、化合物

生成物 1

HCID 178465512HCID 178465512、化合物収率 11%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture containing 2-fluoro-4-{4-[2-(phenoxymethyl)-1H-imidazol-4-yl]phenoxy}aniline (1 g, 2.66 mmol) and ethylisothiocyanate (0.31 g, 2.32 mmol) in 20 ml of ethanol is heated for five hours under reflux. The reaction mixture is concentrated in a rotavapor. After passing the residue obtained through a silica column (eluent: dichloromethane/ethanol/liquid ammonia 96/2/2), a yellow-coloured powder is obtained with a yield of 11%.

後処理

  1. temperatureis heated for five hours
  2. temperatureunder reflux
  3. concentrationThe reaction mixture is concentrated in a rotavapor
  4. customobtained through a silica column (eluent: dichloromethane/ethanol/liquid ammonia 96/2/2)
  5. customa yellow-coloured powder is obtained with a yield of 11%

出典と根拠

ORDレコード
ord-01d5d2a813f74421ac648eea71a7ded9
出典データセット
uspto-grants-2012_05
特許番号
US08188133B2

反応ノート

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