反应详情

A mixture containing 2-fluoro-4-{4-[2-(phenoxymethyl)-1H-imidazol-4-yl]phenoxy}aniline (1 g, 2.66 mmol) and ethylisothiocyanate (0.31 g, 2.32 mmol) in 20 ml of ethanol is heated for five hours under reflux. The reaction mixture is concentrated in a rotavapor. After passing the residue obtained through a silica column (eluent: dichloromethane/ethanol/liquid ammonia 96/2/2), a yellow-coloured powder is obtained with a yield of 11%.

1. temperatureis heated for five hours
2. temperatureunder reflux
3. concentrationThe reaction mixture is concentrated in a rotavapor
4. customobtained through a silica column (eluent: dichloromethane/ethanol/liquid ammonia 96/2/2)
5. customa yellow-coloured powder is obtained with a yield of 11%