Trifluoroacetic acid → HCID 45273911, compound

Participants

Reaction Steps

To a mixture of (S)-2-tert-butoxycarbonylamino-4-(3-{3-[4-(pyridin-2-yloxymethyl)-benzyl]-isoxazol-5-yl}-pyridin-2-ylcarbamoyl)-butyric acid 2-dimethylamino-ethyl ester (53 mg, 0.060 mmol; purity of 75%) described in Manufacturing Example 3-2 and dichloromethane (1 mL) was added trifluoroacetic acid (0.5 mL) at room temperature, which was stirred overnight at the same temperature. The solvent was evaporated from the reaction mixture under a reduced pressure, and the residue thus obtained was washed with diethyl ether, so as to obtain the titled compound (46 mg) as di-(trifluoroacetic acid) salt.

Provenance & Evidence