2-(Dimethylamino)ethanol → HCID 59293924, compound

Participants

Reaction Steps

To a mixture of (S)-2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester (300 mg, 0.89 mmol) and acetonitrile (5 mL) were added 2-dimethylaminoethanol (89 μL, 0.89 mmol) and benzotriazol-1-yloxytris-(dimethylamino)-phosphonium hexafluorophosphate (390 mg, 0.89 mmol) at 0° C., which was stirred overnight at room temperature. A 1N sodium hydroxide aqueous solution was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed first with water and then with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure, so s to obtain the titled compound (380 mg, purity of 77%).

Provenance & Evidence