Tritylamine → 6-Trifluoromethyl-2-trityl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

HRID 1930819Notes

Reaction equation

HRID 1930819 reaction equation
Cl[CH2:2][C:3]1[C:8]([CH2:9]Cl)=[CH:7][N:6]=[C:5]([C:11]([F:14])([F:13])[F:12])[CH:4]=1.[C:15]1([C:21]([NH2:34])([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:12][C:11]([F:14])([F:13])[C:5]1[N:6]=[CH:7][C:8]2[CH2:9][N:34]([C:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:2][C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 138598TritylamineHCID 57753353HCID 57753353, compound

Product 1

HCID 577534186-Trifluoromethyl-2-trityl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

Procedure

Prepared in analogy to Example A2 (b) from 4,5-Bis-chloromethyl-2-trifluoromethyl-pyridine and triphenylmethylamine. White solid.

Sources & evidence

ORD record
ord-8278a60c658e40f59c5101ec9be35250
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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