HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylthiophene → 5-(5-Methyl-thiophen-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylthiophene | HCID 638584 | — |
| Reactant | Tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)isoindoline-2-carboxylate | HCID 16102684 | — |
| Product | 5-(5-Methyl-thiophen-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester | HCID 57753464 | — |
Reaction Steps
Prepared in analogy to Example A23(b) from 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and 4-bromo-2-methylthiophene (commercial). Light yellow solid. MS (m/e): 315.2 ([M]+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-660f66041daf4ede9d8e3f6488d0f47a |
| Source note | uspto-grants-2012_05 |