反应详情

7.7 mmol Dimethyl-[(E)-2-(2-nitro-6-trifluoromethyl-phenyl)-vinyl]-amine was dissolved in 20 ml methanol. 200 mg of palladium 5% on charcoal was added and the reaction mixture hydrogenated at room temperature and atmospheric pressure. When no further hydrogen is absorbed (ca. 3 hours), the reaction mixture is filtered, concentrated and dissolved in diethyl ether. The organic phase is washed with 2 M hydrochloric acid and brine and concentrated to yield the title compound as a yellowish solid. Yield=58%. MS (m/e): 184.9 ([M+H]+, 100%).

1. customhydrogenated at room temperature
2. customWhen no further hydrogen is absorbed (ca. 3 hours)
3. filtrationthe reaction mixture is filtered
4. concentrationconcentrated
5. dissolutiondissolved in diethyl ether
6. washThe organic phase is washed with 2 M hydrochloric acid and brine
7. concentrationconcentrated