4,4-Difluoropiperidine hydrochloride → HCID 57753513, compound

HRID 1930865Notes

Reaction equation

HRID 1930865 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[F:19][C:20]1([F:26])[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:23]3[CH2:24][CH2:25][C:20]([F:26])([F:19])[CH2:21][CH2:22]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27583514,4-Difluoropiperidine hydrochlorideHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 57753513HCID 57753513, compound

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 4,4-difluoropiperidine hydrochloride. Yellow solid. MS (m/e): 339.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-e741f250491040719f8fb4fb6299ee8a
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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