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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930872Generated: October 30, 2026

Hydrochloric Acid → 5-Ethyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

https://huagongshe.com/reaction/1930872

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Ethyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753572—
Product5-Ethyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochlorideHCID 68824290—

Reaction Steps

Prepared in analogy to Example A3(e) from 5-ethyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. White solid. MS (m/e): 216.4 ([M+H]+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08188139B2
Source datasetuspto-grants-2012_05
ORD IDord-3a3bf41d1d3f46e4919c8b65f355160b
Source noteuspto-grants-2012_05