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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930896Generated: October 30, 2026

Trifluoroacetic acid → 5-(3-Methoxy-azetidin-1-yl)-2,3-Dihydro-1H-isoindole trifluoro-acetate

https://huagongshe.com/reaction/1930896

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant5-(3-Methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl EsterHCID 57753325—
Product5-(3-Methoxy-azetidin-1-yl)-2,3-Dihydro-1H-isoindole trifluoro-acetateHCID 68822314—

Reaction Steps

Prepared in analogy to Example A2(c) from 5-(3-methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester and trifluoroacetic acid. Brown foam. MS (m/e): 205.1 ([M+H], 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08188139B2
Source datasetuspto-grants-2012_05
ORD IDord-320b3e75d8b84a009ae6be3a19117d65
Source noteuspto-grants-2012_05