tert-Butyl 5-iodoisoindoline-2-carboxylate → HCID 57753384, compound

HRID 1930899Notes

Reaction equation

HRID 1930899 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[C@H:25]12[CH2:31][C@H:28]([NH:29][CH2:30]1)[CH2:27][O:26]2>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:29]3[CH2:30][C@@H:25]4[CH2:31][C@H:28]3[CH2:27][O:26]4)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylateHCID 68824959HCID 68824959, compound

Product 1

HCID 57753384HCID 57753384, compound

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane trifluoroacetate. Orange oil. MS (m/e): 317.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-5322330b4b6d45c090828d5b8babf710
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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