HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Tributylstannyl-3,6-dihydro-2H-pyran → 5-Chloro-6-(3,6-dihydro-2H-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Tributylstannyl-3,6-dihydro-2H-pyran | HCID 22252258 | — |
| Reactant | 5-Chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic Acid Tert-Butyl Ester | HCID 57753455 | — |
| Product | 5-Chloro-6-(3,6-dihydro-2H-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester | HCID 57753636 | — |
Reaction Steps
Prepared in analogy to Example A49(a) from 5-chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A3(c)) and tributyl-(3,6-dihydro-2H-pyran-4-yl)-stannane. Yellow solid. MS (m/e): 282.3 ({37Cl}[M+H-Me2C═CH2]+, 49%), 280.3 ({35Cl}[M+H-Me2C═CH2]+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c3e38f5a711e468894c7d3e2de68dba3 |
| Source note | uspto-grants-2012_05 |