HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 2-Benzyl-5-(2,5-dihydro-furan-3-yl)-2,3-dihydro-1H-isoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 3-(2-Benzyl-2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-furan-3-ol | HCID 57753389 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Benzyl-5-(2,5-dihydro-furan-3-yl)-2,3-dihydro-1H-isoindole | HCID 57753444 | — |
Reaction Steps
Prepared in analogy to Example A65(a) from 3-(2-benzyl-2,3-dihydro-1H-isoindol-5-yl)-tetrahydro-furan-3-ol (Example A66(a)) and methanesulfonyl chloride, triethylamine, and DBU. Brown solid. MS (m/e): 278.0 ([M+H]+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4efdea47e16741d0ad4e114d1e196aa9 |
| Source note | uspto-grants-2012_05 |