2-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindole → 5-((2S,6R)-2,6-Dimethyl-tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole

HRID 1930930Notes

Reaction equation

HRID 1930930 reaction equation
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH2:18][C@H:19]([CH3:24])[O:20][C@H:21]([CH3:23])[CH:22]=3)[CH:14]=2)[CH2:9]1)C1C=CC=CC=1.[H][H]>>[CH3:23][C@H:21]1[CH2:22][CH:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18][C@@H:19]([CH3:24])[O:20]1

Participants

3

Reactant 2

HCID 577537092-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindoleHCID 178418361HCID 178418361, compound

Product 1

HCID 577534495-((2S,6R)-2,6-Dimethyl-tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A62(c) from 2-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindole and hydrogen. Brown oil. MS (m/e): 232.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-a26c5725a274422d8ac9a8020cc2e66e
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

Loading…