5-Chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic Acid Tert-Butyl Ester → HCID 68822122, compound

HRID 1930945Notes

Reaction equation

HRID 1930945 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12](I)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[C@H:26]12[CH2:32][C@H:29]([NH:30][CH2:31]1)[CH2:28][O:27]2>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:30]3[CH2:31][C@@H:26]4[CH2:32][C@H:29]3[CH2:28][O:27]4)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 577534555-Chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic Acid Tert-Butyl EsterHCID 68824959HCID 68824959, compound

Product 1

HCID 68822122HCID 68822122, compound

Procedure

Prepared in analogy to Example A3(d) from 5-chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A3(c)) and (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane trifluoroacetate. Light yellow solid. MS (m/e): 353.1 ([{37Cl}M+H]+, 36%), 351.1 ([{35Cl}M+H]+, 100%).

Sources & evidence

ORD record
ord-cf4b3ee7346546f783331b827ee840d3
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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