HCID 57753620, compound → HCID 57753505, compound

HRID 1930953Notes

Reaction equation

HRID 1930953 reaction equation
C([N:14]1[CH2:22][C:21]2[C:16](=[CH:17][C:18]([CH:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[C:19]([F:23])[CH:20]=2)[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1>CO.[Pd]>[F:23][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][C:18]=1[CH:24]1[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1)[CH2:15][NH:14][CH2:22]2

Participants

4

Reactant 1

HCID 57753620HCID 57753620, compound

Product 1

HCID 57753505HCID 57753505, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution 0.12 mmol 2-benzhydryl-5-fluoro-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole in 4 ml methanol was added 4 mg 10% palladium on charcoal and the mixture was stirred under an atmosphere of hydrogen for 16 h. The reaction mixture was then filtered and the filtrate was concentrated in vacuo to yield the title compound as a yellow solid (100% yield). MS (m/e): 222.1 ([M+H]+, 100%).

Workup

  1. filtrationThe reaction mixture was then filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-130d0534ab2648b88c1d8ffa6378ea58
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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