HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-propanol → 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-propanol | HCID 9774 | — |
| Reactant | 2-Chloro-5-(methylsulphonyl)benzoic acid | HCID 2329132 | — |
| Product | 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid | HCID 21100306 | — |
Reaction Steps
Prepared in analogy to Example B1 (b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example B1(a)) and rac-1,1,1-trifluoro-propan-2-ol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 311.3 ([M−H]−, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-cd10953f62e34a929e006a70b1aab62c |
| Source note | uspto-grants-2012_05 |