HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930987Generated: October 31, 2026
Methanol → 2-Hydroxy-5-methylsulfamoyl-benzoic acid methyl ester
https://huagongshe.com/reaction/1930987
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Hydroxy-5-methylsulfamoyl-benzoic acid | HCID 14490061 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Hydroxy-5-methylsulfamoyl-benzoic acid methyl ester | HCID 23046763 | — |
Reaction Steps
To 77 mmol 2-hydroxy-5-methylsulfamoyl-benzoic acid in 300 ml THF was added 85 mmol CDI and the mixture heated at 70° C. for 1 h. 770 mmol methanol was then added and the mixture was heated at 70° C. for 16 h. The mixture was then cooled to room temperature and concentrated in vacuo. The residue was chromatographed on silica gel (eluant: ethyl acetate/heptane/dichloromethane 45:45:10) to afford the title compound. MS (m/e): 244.1 ([M−H]−, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08188139B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-d37d3349d92a4cad806a144980cff62a |
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| Source note | uspto-grants-2012_05 |
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