4-Chlorophenylboronic acid → 4'-Chloro-4-methanesulfonyl-biphenyl-2-carboxylic acid

HRID 1931011Notes

Reaction equation

HRID 1931011 reaction equation
I[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[C:3]([C:4]([OH:6])=[O:5])=[CH:7][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:9][CH:10]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 574452812-Iodo-5-methanesulfonyl-benzoic acid

Product 1

HCID 577533364'-Chloro-4-methanesulfonyl-biphenyl-2-carboxylic acid

Procedure

Prepared in analogy to Example B25 from 2-Iodo-5-methanesulfonyl-benzoic acid (example B19(b)) and 4-chloro-benzeneboronic acid. Light brown solid. MS (m/e): 309.1 ([M−H], 100%).

Sources & evidence

ORD record
ord-9017fb5439254aa4a82dcd323b1a434b
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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