(1,1'-Biphenyl)-4-sulphonyl chloride → (E)-3-[1-(Biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6](=[O:14])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][NH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:15]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[C:1]([O:5][C:6](=[O:14])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:21]([C:18]2[CH:17]=[CH:16][C:15]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:20][CH:19]=2)(=[O:23])=[O:22])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
(compound D1) (0.531 g), 4-biphenylsulphonylchloride (0.834 g). Reaction conditions: −30° C., 10 min; −30° C., 30 min.
Workup
- customReaction conditions
- custom−30° C., 10 min
- custom−30° C., 30 min.
Sources & evidence
- ORD record
- ord-740e7ab76f7844ecba8135e0bb92e45f
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08188138B2
Reaction notes
Loading…