4-(1H-pyrazol-1-yl)benzene-1-sulfonyl chloride → (E)-3-[1-(4-Pyrazol-1-yl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

HRID 1931055Notes

Reaction equation

HRID 1931055 reaction equation
[C:1]([O:5][C:6](=[O:14])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][NH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N:15]1([C:20]2[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=2)[CH:19]=[CH:18][CH:17]=[N:16]1>>[C:1]([O:5][C:6](=[O:14])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:26]([C:23]2[CH:22]=[CH:21][C:20]([N:15]3[CH:19]=[CH:18][CH:17]=[N:16]3)=[CH:25][CH:24]=2)(=[O:27])=[O:28])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27764754-(1H-pyrazol-1-yl)benzene-1-sulfonyl chlorideHCID 66646340tert-butyl (2E)-3-(1H-pyrrol-3-yl)prop-2-enoate2×

Product 1

HCID 66646252(E)-3-[1-(4-Pyrazol-1-yl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

Procedure

Starting from (E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester (compound D1) and art-known 4-pyrazol-1-yl-benzenesulfonylchloride the title compound can be obtained analogously or similarly as described for compound C1.

Sources & evidence

ORD record
ord-2bb3a1446df54847b8359b2dd8c710c5
Source dataset
uspto-grants-2012_05
Patent number
US08188138B2

Reaction notes

Loading…