Ammonium → N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-2,6-difluorobenzenesulfonamide

HRID 193107Notes

Reaction equation

HRID 193107 reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][O:44][CH2:45]1.[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][cH:34][c:35]2[F:36])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]1.[NH4+:39].[OH-:38]>>[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][cH:34][c:35]2[F:36])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([NH2:39])[n:16][cH:17][cH:18]1

Participants

5

Reactant 4

HCID 223AmmoniumHCID 961HydroxideHCID 312751,4-DioxaneHCID 57989885N-{2-Chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989943N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-705c229d83d144339c067df669af0d95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…