tetrahydrofuran N,N-dimethylformamide → HCID 87087541, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of Example 69A (20.0 g, 78.0 mmol) and Example 39A (21.9 g, 85.0 mmol) in THF/DMF (4/1) was added potassium 2-methylpropan-2-olate (13.1 g, 117 mmol). The mixture was heated at 75° C. for 16 hours then cooled to room temperature, diluted with ether and washed with aqueous NaHCO3. The organic extract was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography on SiO2 using an Analogix® Intelliflash280™ (Hexanes:EtOAc, 0 to 50% gradient) to afford the title compound. MS (ESI+) m/z 342 (M+H)+.

Provenance & Evidence