o-Iodonitrobenzene → HCID 24821369, compound

Participants

Reaction Steps

Method A applied to 1-iodo-2-nitrobenzene (125 mg, 0.5 mmol) and 5-phenylcarbamoyl-pentanoic acid methyl ester (141 mg, 0.6 mmol) yielded the title compound as brown oil (136 mg, 88%). 1H NMR (DMSO) δ 1.50-1.74 (m, 4H), 2.27 (d, J=7.2Hz, 2H), 2.89 (d, J=7.5Hz, 2H), 3.52 (s, 3H), 7.22 (d, J=8.1Hz, 1H), 7.38 (apparent t, J=7.6Hz, 1H), 7.46 (apparent t, J=7.6Hz, 1H), 7.52-7.72 (m, 5H), 7.79 (d, J=7.8 Hz, 1H); 13C NMR δ 23.3, 25.3, 25.4, 32.2, 50.9, 111.3, 115.6, 124.3, 124.4, 126.8, 130.0, 132.4, 133.2, 133.4, 153.9, 172.3. HRMS (FAB): cal. for C19H21N2O2 [M+H+]: 309.1603; found: 309.1595.

Provenance & Evidence