HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Iodonitrobenzene → 2-Methyl-1-(pyridin-2-yl)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Iodonitrobenzene | HCID 69115 | — |
| Reactant | 2-Acetamidopyridine | HCID 72929 | — |
| Product | 2-Methyl-1-(pyridin-2-yl)-1H-benzimidazole | HCID 22736643 | 38.2% |
Reaction Steps
Method A applied to 1-iodo-2-nitrobenzene (125 mg, 0.5 mmol) and 2-acetamido-pyridine (82 mg, 0.6 mmol) yielded the title compound as yellowy oil (40 mg, 38%). 1H NMR (DMSO) δ 2.74 (s, 3H), 7.42-7.49 (m, 2H), 7.56 (d, 1H), 7.70 (dd, 1H), 7.78-7.88 (m, 2H), 8.22 (dd, 1H), 8.77 (dd, 1H); 13C NMR δ 13.6, 112.0, 116.1, 121.0, 124.7, 124.9, 133.0, 135.2, 140.1, 147.2, 150.0, 151.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188282B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-00e9682a48db4a13a0ab5fb3a63d39c1 |
| Source note | uspto-grants-2012_05 |