Hydrogen chloride-ethyl acetate → HCID 68430374, compound

HRID 1931298Notes

Reaction equation

HRID 1931298 reaction equation
[ClH:1].C(OCC)(=O)C.[CH:8]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C@H:21]2[C@H:26]3[CH2:27][CH2:28][C@H:23]([CH2:24][N:25]3C(OC(C)(C)C)=O)[CH2:22]2)=[O:20])=[CH:14][CH:13]=1)([CH3:10])[CH3:9]>C(Cl)(Cl)Cl>[ClH:1].[CH:8]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C@H:21]2[C@H:26]3[CH2:27][CH2:28][C@H:23]([CH2:24][NH:25]3)[CH2:22]2)=[O:20])=[CH:14][CH:13]=1)([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86649436HCID 86649436, compound

Product 1

HCID 68430374HCID 68430374, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A 4 N-hydrochloric acid-ethyl acetate solution (8.1 mL) was added to a chloroform (10 mL) solution of the compound (1.26 g, 3.24 mmol) synthesized in (3), and the mixture was stirred at room temperature for 13 hours. The reaction mixture was then concentrated under reduced pressure to obtain the title compound (1.15 g, 100%).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-5cf32f31301f4a1480d93540177146cd
Source dataset
uspto-grants-2012_05
Patent number
US08188280B2

Reaction notes

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