Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-Oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid | HCID 45117420 | — |
| Reactant | HCID 57470208 | HCID 57470208 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25225864 | HCID 25225864 | — |
Reaction Steps
To 4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid (48 mg, 0.25 mmol), 5-tert-butyl-1H-indol-6-amine (48 mg, 0.25 mmol) in DMF (1 mL) was added HATU (106 mg, 0.28 mmol), followed by triethylamine (106 μL, 0.76 mmol) and the reaction mixture was heated at 80° C. for 16 h. The reaction mixture was then purified by reverse phase HPLC 10-99% ACN in water to give N-(5-tert-butyl-1H-indol-6-yl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxamide. MS m/z: 361.5 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08188283B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-295d17433ce74967bf0d8d94611c25c1 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
