HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Adamantan-2-yl-3-(4-hydroxy-2-methyl-phenyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 1-Adamantan-2-yl-3-(4-methoxy-2-methyl-phenyl)-urea | HCID 16126882 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Adamantan-2-yl-3-(4-hydroxy-2-methyl-phenyl)-urea | HCID 23582344 | 92.8% |
Reaction Conditions
| Temperature | -78 °C |
|---|
Reaction Steps
To a suspension of 1-adamantan-2-yl-3-(4-methoxy-2-methyl-phenyl)-urea 1.56 g (4.88 mmol) in DCM 20 ml was added at −78° C. under argon a solution of boron tribromide 1M in DCM 14.67 ml (14.67 mmol). The reaction mixture was stirred at −78° C. for 1 h then allowed to reach room temperature. Water 60 ml was added, the precipitate was filtered, washed with water and dried under vacuum to give 1.36 g (92%) a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188288B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d0625fb299cf442e92c0cc9bdf34a123 |
| Source note | uspto-grants-2012_05 |