Hydrochloric Acid → 3-(5-Bromo-2-thienyl)-2-propenoic acid

Participants

Reaction Steps

3 g (15.7 mmol) of 5-Bromo-thiophene-2-carbaldehyde were dissolved in 30 ml of pyridine and 1.96 g (18.8 mmol) of malonic acid and 133 mg (1.6 mmol) of piperidine were added. The resulting solution was boiled under reflux for 6 h. The solution was cooled to room temperature and then poured into a mixture of ice and concentrated hydrochloric acid. The precipitated product was isolated by filtration, dissolved in ethyl acetate and washed with 0.1 M hydrochloric acid. The organic phase was dried with sodium sulfate, filtered, and the solvent was removed under reduced pressure. Yield: 3.0 g.

Provenance & Evidence