反应详情

95 mg (0.326 mmol) of 2-(6-bromo-pyridazin-3-yloxy)-(1-piperidin-1-yl)-ethanone, 46.7 mg (0.334 mmol) 4-fluoro-phenylboronic acid, 11 mg (0.01 mmol) of tetrakis(triphenylphosphine)palladium and 0.5 ml of a 1 M aqueous sodium carbonate solution in 15 ml of DME were heated under reflux for 3 h. After cooling, the mixture was poured onto water and extracted with ethyl acetate. The combined organic phases were dried and evaporated, and the product was purified by RP18 chromatography. Yield: 73 mg.

1. temperatureunder reflux for 3 h
2. temperatureAfter cooling
3. additionthe mixture was poured onto water
4. extractionextracted with ethyl acetate
5. customThe combined organic phases were dried
6. customevaporated
7. customthe product was purified by RP18 chromatography