Methanol → HCID 68535097, compound

HRID 1931393Notes

Reaction equation

HRID 1931393 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]([CH:13]=[CH:14][C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1.[CH3:18]O>[Pd]>[CH3:18][O:16][C:15](=[O:17])[CH2:14][CH2:13][C:11]1[S:12][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 53412006HCID 53412006, compound

Product 1

HCID 68535097HCID 68535097, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

100 mg of 5% palladium on carbon were added to a solution of 5 g (20.1 mmol) of 3-[5-(2-fluoro-phenyl)-thiophen-2-yl]-acrylic acid in 200 ml of methanol, and the reaction mixture was hydrogenated at atmospheric pressure and room temperature for 7 days. The mixture was filtered and evaporated. The product was purified by silica gel chromatography. Yield: 2.9 g.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated
  3. customThe product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-ba95fd4650734897a7713f1bf7ed0b62
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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