HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → HCID 68535124, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | 3-(6-Phenoxypyridin-3-yl)prop-2-enoic acid | HCID 2797743 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68535124 | HCID 68535124 | — |
Reaction Steps
0.15 g (0.62 mmol) of 3-(6-phenoxy-pyridin-3-yl)-acrylic acid, 1.72 g (15 mmol) of NEM and 546 mg (1.6 mmol) of TOTU were dissolved in 5 ml of DMF and stirred at room temperature for 15 min. 163 mg (1.626 mmol) of piperazin-2-one were added and the reaction mixture was stirred at room temperature for 16 h. After evaporation, the product was purified by silica gel chromatography. Yield: 153 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188291B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8c5e282c1e674107ae6c3624f04cfed4 |
| Source note | uspto-grants-2012_05 |