Cyclopropylamine → HCID 59152256, compound

HRID 1931412Notes

Reaction equation

FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1>>[CH:25]1([NH:28][C:22](=[O:24])[CH2:21][O:20][C:17]2[S:18][CH:19]=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=3)[N:16]=2)[CH2:27][CH2:26]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 68536712HCID 68536712, compound

Product 1

HCID 59152256HCID 59152256, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroacetic acid salt and 31.1 mg (0.54 mmol) of cyclopropylamine. Yield: 21.5 mg.

Sources & evidence

ORD record: ord-9088114f871940029fec170c07ed8fd6
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

Loading…