HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid | HCID 68535118 | — |
| Product | 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionyl chloride hydrochloride | HCID 86638123 | — |
Reaction Steps
The title compound was prepared in quantitative yield by boiling 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid in thionyl chloride, followed by removal of the volatiles by coevaporating three times with toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188291B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a44ee74777e746109468df1306419541 |
| Source note | uspto-grants-2012_05 |