Cyclopropylamine → N-Cyclopropyl-2-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetamide trifluoroacetic acid salt

HRID 1931426Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:25]1([NH:28][C:22](=[O:24])[CH2:21][NH:20][C:17]2[S:18][CH:19]=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=3)[N:16]=2)[CH2:27][CH2:26]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 86638128N-Cyclopropyl-2-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 31.2 mg (0.54 mmol) of cyclopropylamine. Yield: 53 mg.

Sources & evidence

ORD record: ord-23e776aa90c9497e8d1ed2401616b7eb
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

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