Aniline → 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n-phenyl-acetamide trifluoroacetic acid salt

HRID 1931427Notes

Reaction equation

HRID 1931427 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([NH:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 866381292-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n-phenyl-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 50.8 mg (0.54 mmol) of aniline. Yield: 4.7 mg.

Sources & evidence

ORD record
ord-cd273162e98547a2aa1c8361cb018d61
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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